Produced by W2D1 Media. Work with us →

Main Sequence Ventures

Main Sequence Ventures is a venture capital firm that focuses on investing in deep tech and science-driven companies. They aim to support and accelerate the growth of startups that are working on transformative technologies and innovations. Main Sequence Ventures is known for its commitment to fostering companies that have the potential to solve significant global challenges and create new industries. The firm collaborates with entrepreneurs, researchers, and industry experts to bring groundbreaking ideas to market. Their investment strategy is centered around nurturing companies that operate at the intersection of science, engineering, and business, with a strong emphasis on sustainability and positive societal impact.

Sector
Venture capital (deep tech)
Business model
Venture fund (deep tech)
Markets
Australia

Sources: mseq.vc, csiro.au

3people interviewed
4episodes across 4 shows
4mentions in other conversations

The team on Day One

Hear from the team

Milestones

  1. 2017 Founded by CSIRO to commercialise Australian public research csiro.au
  2. July 2023 Raised A$450M Fund 3, taking funds under management past A$1B csiro.au

What others say about Main Sequence Ventures

Moments from other conversations on the network where Main Sequence Ventures comes up.

That initial thinking done by Beau Lees and a few others, including Bill Bartee and Phil Maul and Larry Marshall, resulted in the creation of Main Sequence Ventures, which has had a massive impact on that science commercialisation research commercialisation space.”
On Documentary: The History Of The Australian Startup Ecosystem The History Of The Australian Startup Ec… · 12:54 ▶
the CSIRO Main Sequence Ventures Fund, of course, is one of the funds that I started.”
Malcolm TurnbullManaging Director, Turnbull and Partners The History of the Australian Startup Ecosystem - Interview Series · Malcolm Turnbull discusses innovation in… · 15:21 ▶
I'm very proud of what we do at Main Sequence Ventures. I'm on the investment committee for Main Sequence Ventures, and we've now got about a $500 million, two funds, two and then two full-on funds worth about $500 million.”
On The History of the Australian Startup Ecosystem - Interview Series Sarah Pearson on the importance of coope… · 18:23 ▶
That initial thinking done by Beau Lees and a few others, including Bill Bartee and Phil Maul and Larry Marshall, resulted in the creation of Main Sequence Ventures, which has had a massive impact on that science commercialization, research commercialization space.”
David BurtDirector of Entrepreneurship, UNSW Founders The History of the Australian Startup Ecosystem - Interview Series · David Burt explains why startups are ess… · 8:10 ▶

In the news

Portfolio on Day One

Companies Main Sequence Ventures has backed whose teams have been on the network.

Alumni on Day One

People who worked at Main Sequence Ventures before, and what they're doing now.

Thinking of working at Main Sequence Ventures?

Hear how the team works in their own words, then see the open roles.

More investor companies on Day One

Spot something wrong? Suggest a correction Updated 25 September 2026

—