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About Prash Puspanathan

Dr Prash Puspanathan is a psychiatrist and co-founder of Enosis Therapeutics, which aims to make psychedelic-assisted psychotherapy more accessible and its results longer lasting. He is also helping develop treatment protocols for psychedelic-assisted therapy within Australia's legal frameworks.

In 2016 he co-founded Caleb & Brown, a crypto brokerage for private clients in Australia and the United States, with Rupert Hackett. In July 2025 Swyftx agreed to acquire the business in what it called the largest crypto acquisition in Australian and New Zealand history.

On Perspective X with Pauline Fetaui, he talked about building Caleb & Brown and his work in psychedelic therapy.

In conversation.

1 episode

Go straight to the good bits.

Key moments from Dr. Prash on Building a $100M+ Crypto Brokerage and Pioneering Psychedelic Therapy.

  1. 2:00From surgery to psychiatry: psychedelics as a turning point
  2. 6:30The transformative psilocybin experience and shifting paradigms
  3. 10:30Understanding psychedelic therapy and integration work
  4. 16:00Why psychedelics challenge power structures and cultural norms
  5. 22:00Fiscal freedom and cognitive freedom: psychedelics and Bitcoin
  6. 30:00Founding Caleb & Brown and building a billion-dollar brokerage
  7. 37:00Global scaling, high-net-worth clients, and leadership transitions
  8. 42:00Preparing for acquisition: the 9-month journey to Swyftx
  9. 50:00Running a dual life as psychiatrist and founder
  10. 55:00Enosis Therapeutics: VR-powered integration for psychedelic therapy

The path so far.

  1. Now

    Co-founder · Enosis Therapeutics

  2. From 2016 · Startup

    Co-founder · Caleb & Brown

Sources: robbreport.com.sg

Enosis Therapeutics on Day One

Enosis Therapeutics is a Melbourne medical technology and psychedelic research company that designs virtual reality scenarios for use during psychedelic-assisted…

1 person · 1 episode
Enosis Therapeutics

Across the network.

Spot something wrong? Suggest a correctionUpdated 29 October 2026

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